Colleen L. Doçi, Ph.D.
Associate Professor of Exercise and Sports Science

Biography

Colleen L. Doçi, Ph.D., is an associate professor of exercise and sports science at the Marian University College of Arts and Sciences. She earned a B.S. in chemistry with biochemistry honors from Purdue University. She then earned a Ph.D. in Cancer Biology from the University of Chicago with a focus on posttranscriptional regulation of angiogenic factors in epithelial cancers. She was awarded a postdoctoral training award from the National Institutes of Health at the National Institute for Dental and Craniofacial Research where she worked on the role of epithelial migration and vascularity in oral cancer metastasis. She has published over a dozen primary research articles, reviews, and book chapters and her work has been featured on the cover of Cancer Research. In 2015, she joined the faculty at Marian focusing on mentoring young scientists. Dr. Doci's research interests center on the role of angiogenic and lymphangiogenic signaling molecules in cancer pathogenesis and metastasis.

Education

• Ph.D. Cancer Biology, The University of Chicago, 2011
• BS Chemistry, Purdue University, 2004

Professional affiliations

• Member, Indiana Academy of Sciences (2015-present) 
• Member, Alpha Chi Sigma Professional Chemistry Fraternity (2004-present)

Courses

• BIO 204 Cell Biology
• BIO 311/312L Biochemistry Lab
• BIO 345 Immunology
• BIO 454 Bioassays
• BMS 545 Immunology

Research interests / portfolio

• Angiogenic and lymphangiogenic signaling
• Cellular migration and cancer metastasis
• Inflammation, wound healing, and immunosurveillance
• Research in higher education

Publications

• Doçi CL* and Mikelis CM*, Callejas-Valera JL, Hansen KK, Molinolo AA, Inoue A, Offermanns S, and Gutkind JS. (2017) Loss of Gα11/q delays cutaneous wound healing through enhanced differentiation-mediated impairment of epithelial migration. PLoS One 12(3):e0173692.
• Sakurai A, Doçi CL, and Gutkind JS. (2017) Using heterologous COS-7 cells to identify semaphorin signaling components. In Chemotaxis: Methods and Protocols. Tian Jin (ed); 2017 Springer International Publishing.
• Doçi CL and Gutkind JS. (2015) The PI3K/mTOR Axis as a Molecular and Therapeutic Target in Oral Squamous Cell Carcinomas. In Human Papilloma Virus (HPV)-Associated Oropharyngeal Cancer. Sharon Stack (ed.); Springer International Publishing.
• Doçi CL, Mikelis CM, Molinolo AA, Amornphimoltham P, and Gutkind JS. (2015) Genetic Identification of SEMA3F as an Antilymphangiogenic Metastasis Suppressor Gene in Head and Neck Squamous Carcinoma. Cancer Research 75(14):2937-48.
• Dillenburg-Pilla P, Patel V, Mikelis CM, Rodrigo Zárate-Bladés C, Doçi CL, Amornphimoltham P, Wang Z, Martin D, Leelahavanichkul K, Dorsam RT, Masedunskas A, Weigert R, Molinolo AA, and Gutkind JS. (2014) A central role for mTORC1 in CXCR4-mediated directional migration and metastasis. FASEB Journal 29(3):1056-68.
• Doçi CL, Zhou G, Lingen MW. (2013) The novel tumor suppressor NOL7 post-transcriptionally regulates thrombospondin-1 expression. Oncogene 32(37):4377-86.
• Patel V, Martin D, Malhotra R, Marsh CA, Doçi CL, Veenstra TD, Nathan CA, Sinha UK, Singh B, Molinolo AA, Rusling JF, and Gutkind JS. (2013) DSG3 as a biomarker for the ultrasensitive detection of occult lymph node metastasis in oral cancer using nanostructured immunoarrays. Oral Oncol 49(2):93-101.
• Sakurai, A, Doçi CL and Gutkind, JS. (2012) Semaphorin signaling in angiogenesis, lymphangiogenesis and cancer. Cell Res 22(1):23-32.
• Doçi CL, Mankame TP, Langerman A, Ostler KR, Onel K, Godley LA, Salgia R., and Lingen MW. (2012) Characterization of point mutations and promoter methylation of the NOL7 tumor suppressor gene in cervical cancer cell lines and tumor specimens. Int J Gynecol Pathol 31:15-19.
• Zhou, G* and Doçi CL*, and Lingen MW. (2010) Identification And Functional Analysis of NOL7 Nuclear And Nucleolar Localization Signals. BMC Cell Biol 11:74.
• Zhou G, Hasina R, Wroblewski K, Mankame TP, Doçi CL, Lingen MW. (2010) Dual Inhibition of VEGFR and EGFR is an Effective Chemopreventive Strategy in the Mouse 4-NQO Model of Oral Carcinogenesis. Cancer Prevention Research 3(11):1493-502.
• Hasina R, Martin LE, Kaza K, Jones CL, Jalil A, and Lingen MW. (2009) ABT-510 Is an Effective Chemopreventive Agent in the Mouse 4-Nitroquinoline 1-Oxide Model of Oral Carcinogenesis. Cancer Prevention Research 2(4): 385-393.

• Main KA, Mikelis CM, and Doçi CL. In Vitro Wound Healing Assays to Investigate Epidermal Migration. In: Methods Mol Biol. 2019 May 24.

• Iglesias-Bartolome R, Uchiyama A, Molinolo AA, Abusleme L, Brooks SR, Callejas-Valera JL, Edwards D, Doci C, Asselin-Labat ML, Onaitis MW, Moutsopoulos NM, Gutkind JS, Morasso MI. Transcriptional signature primes human oral mucosa for rapid wound healing. Sci Transl Med. 2018 Jul 25;10(451).